Medicine Redefined
Dr. Darsh Shah, DO & Dr. Altamash Raja, DO interview practitioners who challenge the norm and promote health during a time when the healthcare system feels broken. Find out how experts in the fields of sleep, nutrition, exercise, stress resilience, rehabilitation, precision & performance medicine, and so many more are using "unconventional" approaches to move the needle forward and redefine medicine as we know it.
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Latest Episode
208. Acid Reflux Isn’t Just an Acid Problem: PPIs, Rebound, and Deprescribing | Badal Shah, DO
EPISODE DESCRIPTION Acid reflux isn't a problem of too much acid. Gastroenterologist Dr. Badal Shah joins Drs. Raja and Shah to break down what's actually failing (the lower esophageal sphincter), how patients end up on PPIs for decades, and how to wean off without rebound. They cover the long-term risks of acid suppression, fiber as the most underrated GI intervention, SIBO vs. leaky gut, what probiotics can and can't do, and why fecal transplants cure recurrent C. diff more than 95% of the tim
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July 21, 2025
179. Is Medicine Worth It? Real Talk on Debt, Purpose, and The Future of Doctors
In this episode of Medicine Redefined, Darsh and Altamash dive deep into the question on every future and current physician’s mind: is medicine still worth it? What starts as a reflection on the financial and emotional toll of the profession quickly evolves into a powerful conversation about agency, reinvention, and longevity in medicine. With honesty and humor, they unpack their own journeys from burnout to building lives and careers on their own terms, sharing hard-earned insights and tactical
Dec. 5, 2022
82. Preventing Cardiovascular Disease, Cholesterol & Lipids, Lifestyle Interventions for a Healthy Heart | Nicole Harkin, MD (Ep 55/56 Rebroadcast)
Dr. Nicole Harkin is board-certified in Internal Medicine, Cardiology, and Lipidology. She earned her medical degree from Boston University and completed residency training at Columbia University followed by a fellowship in Cardiology at New York University, in which she served as a chief fellow. Dr. Harkin is the founder of Whole Heart Cardiology, with the mission of providing patient-centered cardiac care, evidence-based nutritional guidance, and personalized lifestyle plans for her patients i
June 14, 2021
16. Will Bulsiewicz, MD, MSCI - Part I of II: Gut Health, Microbiome, "Leaky Gut," the Truth on Dairy and Gluten
Dr. Will Bulsiewicz, aka Dr. B, is a leader and author in the field of gastroenterology and gut health. His hit book, Fiber Fueled, is a New York Times bestseller that focuses on optimizing the microbiome and restoring health through a plant-based gut health program. He has amassed over 300k followers on social media - @theguthealthmd
In this episode, Dr. B takes us through the importance of a healthy gut and how optimizing it can better express overall health. He also touches on what the microb
In this episode, Dr. B takes us through the importance of a healthy gut and how optimizing it can better express overall health. He also touches on what the microb
Recent Episodes
Aug. 31, 2026
208. Acid Reflux Isn’t Just an Acid Problem: PPIs, Rebound, and Deprescribing | Badal Shah, DO
EPISODE DESCRIPTION Acid reflux isn't a problem of too much acid. Gastroenterologist Dr. Badal Shah joins Drs. Raja and Shah to break down what's actually failing (the lower esophageal sphincter), how patients end up on PPIs for decades, and how to wean off without rebound. They cover the long-term risks of acid suppression, fiber as the most underrated GI intervention, SIBO vs. leaky gut, what probiotics can and can't do, and why fecal transplants cure recurrent C. diff more than 95% of the tim
Aug. 17, 2026
207. Treatment-Resistant Depression: TMS, Ketamine, Spravato, and What Comes Next | Patrick Sullivan, DO
EPISODE DESCRIPTION If antidepressants haven't worked, is that the end of the road? Dr. Patrick "Rocky" Sullivan returns to break down transcranial magnetic stimulation — what it actually does to the brain, how it differs from ECT, and where it fits alongside ketamine and Spravato. He covers accelerated theta burst protocols, why insurance decides your session count, the gap between response and remission, and what clinics are overselling. Treatment-resistant, he argues, doesn't mean untreatable
Aug. 3, 2026
206. FDA Approval on Peptides, Creating a Second Brain with AI, Red Light Therapy, and Building Capacity
Dr. Darsh Shah and Dr. Altamash Raja catch up on hybrid athlete training, peptides, AI, red light therapy, health tech, and the balance between optimization and resilience. From HYROX prep and the rise of competitions like the Lifetime Games to recent peptide committee votes, CMS reimbursement cuts, and AI tools like Claude and ChatGPT, the conversation explores how new trends are changing fitness, medicine, and daily decision-making for both patients and doctors. They also reflect on building
July 20, 2026
205. Beyond Rest and Recovery: What Actually Heals the Brain After Concussion | Marissa McCarthy, MD
Dr. Darsh Shah and Dr. Altamash Raja sit down with Dr. Marissa McCarthy, a board-certified physical medicine and rehabilitation physician, brain injury specialist, and residency program director for the University of South Florida PM&R program. Dr. McCarthy practices at the USF Concussion Center and the Performance Lab in Tampa, where she works with athletes, military veterans, and patients recovering from traumatic brain injury. This conversation goes far beyond the basics of concussion care.
July 6, 2026
Metabolic Flexibility Explained: Why Ketones May Be an Overlooked Health Marker | Dorian Greenow
Dr. Darsh Shah and Dr. Altamash Raja sit down with Dorian Greenow, founder of Keto-Mojo, for a wide-ranging conversation on ketosis, metabolic flexibility, chronic disease, and what it means to make health measurable. Dorian shares how his own experience with weight gain, depression, and discovering nutritional ketosis shaped the creation of Keto-Mojo. From the history of ketogenic diets to the difference between nutritional and therapeutic ketosis, the conversation explores food addiction, ket
June 22, 2026
203. What Medical School Doesn’t Teach About Health, Fulfillment, and Finding Your Why | Brian Devorkin
Dr. Darsh Shah and Dr. Altamash Raja sit down with Brian Devorkin, a third-year medical student at Case Western and host of BackedBriScience, for a wide-ranging conversation on fulfillment, longevity, chronic illness, and the harder questions behind choosing medicine. Brian shares how chronic fatigue and Lyme disease shaped his understanding of health, agency, and what it means to “get your life back.” From his gap year working with longevity researcher David Sinclair to the realities of medica
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